GlutaredoxinV1, Main, Exploration, bibRecord, 000269

Exosomes from patients with septic shock convey miRNAs related to inflammation and cell cycle regulation: new signaling pathways in sepsis?

Identifieur interne : 000269 ( Main/Exploration ); précédent : 000268; suivant : 000270

Exosomes from patients with septic shock convey miRNAs related to inflammation and cell cycle regulation: new signaling pathways in sepsis?

Auteurs : Juliana Monte Real [Brésil] ; Ludmila Rodrigues Pinto Ferreira [Brésil] ; Gustavo Henrique Esteves [Brésil] ; Fernanda Christtanini Koyama [Brésil] ; Marcos Vinícius Salles Dias [Brésil] ; João Evangelista Bezerra-Neto [Brésil] ; Edécio Cunha-Neto [Brésil] ; Flavia Ribeiro Machado [Brésil] ; Reinaldo Salomão [Brésil] ; Luciano Cesar Pontes Azevedo [Brésil]

Source :

Critical care (London, England) [ 1466-609X ] ; 2018.

RBID : pubmed:29540208

Descripteurs français

KwdFr :
- ARN messager (analyse), ARN messager (métabolisme), ARN messager (sang), Adulte (MeSH), Adulte d'âge moyen (MeSH), Brésil (MeSH), Choc septique (métabolisme), Choc septique (physiopathologie), Exosomes (anatomopathologie), Exosomes (composition chimique), Exosomes (métabolisme), Femelle (MeSH), Glutarédoxines (analyse), Glutarédoxines (sang), Humains (MeSH), Inflammation (complications), Inflammation (diagnostic), Inflammation (métabolisme), Myeloperoxidase (analyse), Myeloperoxidase (sang), Mâle (MeSH), Peroxiredoxin III (analyse), Peroxiredoxin III (sang), Protéine M1 à motif en tête de fourche (analyse), Protéine M1 à motif en tête de fourche (sang), Protéines membranaires (analyse), Protéines membranaires (sang), Stress oxydatif (MeSH), Sujet âgé (MeSH), Superoxide dismutase (analyse), Superoxide dismutase (sang), Sélénoprotéines (analyse), Sélénoprotéines (sang), Unités de soins intensifs (organisation et administration), microARN (analyse), microARN (métabolisme), microARN (sang), Études prospectives (MeSH), Évaluation des résultats des patients (MeSH).
MESH :
- analyse : ARN messager, Glutarédoxines, Myeloperoxidase, Peroxiredoxin III, Protéine M1 à motif en tête de fourche, Protéines membranaires, Superoxide dismutase, Sélénoprotéines, microARN.
- anatomopathologie : Exosomes.
- composition chimique : Exosomes, Inflammation.
- diagnostic : Inflammation.
- métabolisme : ARN messager, Choc septique, Exosomes, Inflammation, microARN.
- organisation et administration : Unités de soins intensifs.
- physiopathologie : Choc septique.
- sang : ARN messager, Glutarédoxines, Myeloperoxidase, Peroxiredoxin III, Protéine M1 à motif en tête de fourche, Protéines membranaires, Superoxide dismutase, Sélénoprotéines, microARN.
- Adulte, Adulte d'âge moyen, Brésil, Femelle, Humains, Mâle, Stress oxydatif, Sujet âgé, Études prospectives, Évaluation des résultats des patients.
Wicri :
- geographic : Brésil.

English descriptors

KwdEn :
- Adult (MeSH), Aged (MeSH), Brazil (MeSH), Exosomes (chemistry), Exosomes (metabolism), Exosomes (pathology), Female (MeSH), Forkhead Box Protein M1 (analysis), Forkhead Box Protein M1 (blood), Glutaredoxins (analysis), Glutaredoxins (blood), Humans (MeSH), Inflammation (complications), Inflammation (diagnosis), Inflammation (metabolism), Intensive Care Units (organization & administration), Male (MeSH), Membrane Proteins (analysis), Membrane Proteins (blood), MicroRNAs (analysis), MicroRNAs (blood), MicroRNAs (metabolism), Middle Aged (MeSH), Oxidative Stress (MeSH), Patient Outcome Assessment (MeSH), Peroxidase (analysis), Peroxidase (blood), Peroxiredoxin III (analysis), Peroxiredoxin III (blood), Prospective Studies (MeSH), RNA, Messenger (analysis), RNA, Messenger (blood), RNA, Messenger (metabolism), Selenoproteins (analysis), Selenoproteins (blood), Shock, Septic (metabolism), Shock, Septic (physiopathology), Superoxide Dismutase (analysis), Superoxide Dismutase (blood).
MESH :
- chemical , analysis : Forkhead Box Protein M1, Glutaredoxins, Membrane Proteins, MicroRNAs, Peroxidase, Peroxiredoxin III, RNA, Messenger, Selenoproteins, Superoxide Dismutase.
- chemical , blood : Forkhead Box Protein M1, Glutaredoxins, Membrane Proteins, MicroRNAs, Peroxidase, Peroxiredoxin III, RNA, Messenger, Selenoproteins, Superoxide Dismutase.
- chemical , metabolism : MicroRNAs, RNA, Messenger.
- geographic : Brazil.
- chemistry : Exosomes.
- complications : Inflammation.
- diagnosis : Inflammation.
- metabolism : Exosomes, Inflammation, Shock, Septic.
- organization & administration : Intensive Care Units.
- pathology : Exosomes.
- physiopathology : Shock, Septic.
- Adult, Aged, Female, Humans, Male, Middle Aged, Oxidative Stress, Patient Outcome Assessment, Prospective Studies.

Abstract

BACKGROUND

Exosomes isolated from plasma of patients with sepsis may induce vascular apoptosis and myocardial dysfunction by mechanisms related to inflammation and oxidative stress. Despite previous studies demonstrating that these vesicles contain genetic material related to cellular communication, their molecular cargo during sepsis is relatively unknown. In this study, we evaluated the presence of microRNAs (miRNAs) and messenger RNAs (mRNAs) related to inflammatory response and redox metabolism in exosomes of patients with septic shock.

METHODS

Blood samples were collected from 24 patients with septic shock at ICU admission and after 7 days of treatment. Twelve healthy volunteers were used as control subjects. Exosomes were isolated by ultracentrifugation, and their miRNA and mRNA content was evaluated by qRT-PCR array.

RESULTS

As compared with healthy volunteers, exosomes from patients with sepsis had significant changes in 65 exosomal miRNAs. Twenty-eight miRNAs were differentially expressed, both at enrollment and after 7 days, with similar kinetics (18 miRNAs upregulated and 10 downregulated). At enrollment, 35 differentially expressed miRNAs clustered patients with sepsis according to survival. The pathways enriched by the miRNAs of patients with sepsis compared with control subjects were related mostly to inflammatory response. The comparison of miRNAs from patients with sepsis according to hospital survival demonstrated pathways related mostly to cell cycle regulation. At enrollment, sepsis was associated with significant increases in the expression of mRNAs related to redox metabolism (myeloperoxidase, 64-fold; PRDX3, 2.6-fold; SOD2, 2.2-fold) and redox-responsive genes (FOXM1, 21-fold; SELS, 16-fold; GLRX2, 3.4-fold). The expression of myeloperoxidase mRNA remained elevated after 7 days (65-fold).

CONCLUSIONS

Exosomes from patients with septic shock convey miRNAs and mRNAs related to pathogenic pathways, including inflammatory response, oxidative stress, and cell cycle regulation. Exosomes may represent a novel mechanism for intercellular communication during sepsis.

DOI: 10.1186/s13054-018-2003-3
PubMed: 29540208
PubMed Central: PMC5852953

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000255
to stream Main, to step Curation: 000255

Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en">Exosomes from patients with septic shock convey miRNAs related to inflammation and cell cycle regulation: new signaling pathways in sepsis?</title>
<author><name sortKey="Real, Juliana Monte" sort="Real, Juliana Monte" uniqKey="Real J" first="Juliana Monte" last="Real">Juliana Monte Real</name>
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<affiliation wicri:level="4"><nlm:affiliation>Sao Paulo State Cancer Institute, University of São Paulo, São Paulo, Brazil.</nlm:affiliation>
<country xml:lang="fr">Brésil</country>
<wicri:regionArea>Sao Paulo State Cancer Institute, University of São Paulo, São Paulo</wicri:regionArea>
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</placeName>
<orgName type="university">Université de São Paulo</orgName>
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<affiliation wicri:level="3"><nlm:affiliation>Hospital do Servidor Publico Estadual de São Paulo, São Paulo, Brazil.</nlm:affiliation>
<country xml:lang="fr">Brésil</country>
<wicri:regionArea>Hospital do Servidor Publico Estadual de São Paulo, São Paulo</wicri:regionArea>
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<region type="state">État de São Paulo</region>
</placeName>
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<author><name sortKey="Ferreira, Ludmila Rodrigues Pinto" sort="Ferreira, Ludmila Rodrigues Pinto" uniqKey="Ferreira L" first="Ludmila Rodrigues Pinto" last="Ferreira">Ludmila Rodrigues Pinto Ferreira</name>
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<country xml:lang="fr">Brésil</country>
<wicri:regionArea>Morphology Department, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Belo Horizonte</wicri:regionArea>
<placeName><settlement type="city">Belo Horizonte</settlement>
<region type="state">Minas Gerais</region>
</placeName>
<orgName type="university">Université fédérale du Minas Gerais</orgName>
</affiliation>
<affiliation wicri:level="4"><nlm:affiliation>Laboratory of Immunology, Heart Institute, University of São Paulo, School of Medicine, São Paulo, Brazil.</nlm:affiliation>
<country xml:lang="fr">Brésil</country>
<wicri:regionArea>Laboratory of Immunology, Heart Institute, University of São Paulo, School of Medicine, São Paulo</wicri:regionArea>
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</placeName>
<orgName type="university">Université de São Paulo</orgName>
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<author><name sortKey="Esteves, Gustavo Henrique" sort="Esteves, Gustavo Henrique" uniqKey="Esteves G" first="Gustavo Henrique" last="Esteves">Gustavo Henrique Esteves</name>
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<country xml:lang="fr">Brésil</country>
<wicri:regionArea>Universidade Estadual da Paraíba, Centro de Ciências e Tecnologia, Campina Grande</wicri:regionArea>
<wicri:noRegion>Campina Grande</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Koyama, Fernanda Christtanini" sort="Koyama, Fernanda Christtanini" uniqKey="Koyama F" first="Fernanda Christtanini" last="Koyama">Fernanda Christtanini Koyama</name>
<affiliation wicri:level="1"><nlm:affiliation>Research and Education Institute, Hospital Sirio-Libanes, Rua Professor Daher Cutait 69, São Paulo, SP, 01539-001, Brazil.</nlm:affiliation>
<country xml:lang="fr">Brésil</country>
<wicri:regionArea>Research and Education Institute, Hospital Sirio-Libanes, Rua Professor Daher Cutait 69, São Paulo, SP, 01539-001</wicri:regionArea>
<wicri:noRegion>01539-001</wicri:noRegion>
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<affiliation wicri:level="3"><nlm:affiliation>Ludwig Institute for Cancer Research, São Paulo, Brazil.</nlm:affiliation>
<country xml:lang="fr">Brésil</country>
<wicri:regionArea>Ludwig Institute for Cancer Research, São Paulo</wicri:regionArea>
<placeName><settlement type="city">São Paulo</settlement>
<region type="state">État de São Paulo</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dias, Marcos Vinicius Salles" sort="Dias, Marcos Vinicius Salles" uniqKey="Dias M" first="Marcos Vinícius Salles" last="Dias">Marcos Vinícius Salles Dias</name>
<affiliation wicri:level="3"><nlm:affiliation>International Research Center, A.C.Camargo Cancer Center, São Paulo, Brazil.</nlm:affiliation>
<country xml:lang="fr">Brésil</country>
<wicri:regionArea>International Research Center, A.C.Camargo Cancer Center, São Paulo</wicri:regionArea>
<placeName><settlement type="city">São Paulo</settlement>
<region type="state">État de São Paulo</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bezerra Neto, Joao Evangelista" sort="Bezerra Neto, Joao Evangelista" uniqKey="Bezerra Neto J" first="João Evangelista" last="Bezerra-Neto">João Evangelista Bezerra-Neto</name>
<affiliation wicri:level="4"><nlm:affiliation>Sao Paulo State Cancer Institute, University of São Paulo, São Paulo, Brazil.</nlm:affiliation>
<country xml:lang="fr">Brésil</country>
<wicri:regionArea>Sao Paulo State Cancer Institute, University of São Paulo, São Paulo</wicri:regionArea>
<placeName><settlement type="city">São Paulo</settlement>
<region type="state">État de São Paulo</region>
</placeName>
<orgName type="university">Université de São Paulo</orgName>
</affiliation>
</author>
<author><name sortKey="Cunha Neto, Edecio" sort="Cunha Neto, Edecio" uniqKey="Cunha Neto E" first="Edécio" last="Cunha-Neto">Edécio Cunha-Neto</name>
<affiliation wicri:level="4"><nlm:affiliation>Laboratory of Immunology, Heart Institute, University of São Paulo, School of Medicine, São Paulo, Brazil.</nlm:affiliation>
<country xml:lang="fr">Brésil</country>
<wicri:regionArea>Laboratory of Immunology, Heart Institute, University of São Paulo, School of Medicine, São Paulo</wicri:regionArea>
<placeName><settlement type="city">São Paulo</settlement>
<region type="state">État de São Paulo</region>
</placeName>
<orgName type="university">Université de São Paulo</orgName>
</affiliation>
<affiliation wicri:level="4"><nlm:affiliation>Division of Clinical Immunology and Allergy, School of Medicine, University of São Paulo, São Paulo, Brazil.</nlm:affiliation>
<country xml:lang="fr">Brésil</country>
<wicri:regionArea>Division of Clinical Immunology and Allergy, School of Medicine, University of São Paulo, São Paulo</wicri:regionArea>
<placeName><settlement type="city">São Paulo</settlement>
<region type="state">État de São Paulo</region>
</placeName>
<orgName type="university">Université de São Paulo</orgName>
</affiliation>
</author>
<author><name sortKey="Machado, Flavia Ribeiro" sort="Machado, Flavia Ribeiro" uniqKey="Machado F" first="Flavia Ribeiro" last="Machado">Flavia Ribeiro Machado</name>
<affiliation wicri:level="4"><nlm:affiliation>Federal University of São Paulo, São Paulo, Brazil.</nlm:affiliation>
<country xml:lang="fr">Brésil</country>
<wicri:regionArea>Federal University of São Paulo, São Paulo</wicri:regionArea>
<placeName><settlement type="city">São Paulo</settlement>
<region type="state">État de São Paulo</region>
</placeName>
<orgName type="university">Université de São Paulo</orgName>
</affiliation>
</author>
<author><name sortKey="Salomao, Reinaldo" sort="Salomao, Reinaldo" uniqKey="Salomao R" first="Reinaldo" last="Salomão">Reinaldo Salomão</name>
<affiliation wicri:level="4"><nlm:affiliation>Federal University of São Paulo, São Paulo, Brazil.</nlm:affiliation>
<country xml:lang="fr">Brésil</country>
<wicri:regionArea>Federal University of São Paulo, São Paulo</wicri:regionArea>
<placeName><settlement type="city">São Paulo</settlement>
<region type="state">État de São Paulo</region>
</placeName>
<orgName type="university">Université de São Paulo</orgName>
</affiliation>
</author>
<author><name sortKey="Azevedo, Luciano Cesar Pontes" sort="Azevedo, Luciano Cesar Pontes" uniqKey="Azevedo L" first="Luciano Cesar Pontes" last="Azevedo">Luciano Cesar Pontes Azevedo</name>
<affiliation wicri:level="1"><nlm:affiliation>Research and Education Institute, Hospital Sirio-Libanes, Rua Professor Daher Cutait 69, São Paulo, SP, 01539-001, Brazil. lucianoazevedo@uol.com.br.</nlm:affiliation>
<country xml:lang="fr">Brésil</country>
<wicri:regionArea>Research and Education Institute, Hospital Sirio-Libanes, Rua Professor Daher Cutait 69, São Paulo, SP, 01539-001</wicri:regionArea>
<wicri:noRegion>01539-001</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><nlm:affiliation>Emergency Medicine, University of São Paulo, São Paulo, Brazil. lucianoazevedo@uol.com.br.</nlm:affiliation>
<country xml:lang="fr">Brésil</country>
<wicri:regionArea>Emergency Medicine, University of São Paulo, São Paulo</wicri:regionArea>
<placeName><settlement type="city">São Paulo</settlement>
<region type="state">État de São Paulo</region>
</placeName>
<orgName type="university">Université de São Paulo</orgName>
</affiliation>
</author>
</analytic>
<series><title level="j">Critical care (London, England)</title>
<idno type="eISSN">1466-609X</idno>
<imprint><date when="2018" type="published">2018</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult (MeSH)</term>
<term>Aged (MeSH)</term>
<term>Brazil (MeSH)</term>
<term>Exosomes (chemistry)</term>
<term>Exosomes (metabolism)</term>
<term>Exosomes (pathology)</term>
<term>Female (MeSH)</term>
<term>Forkhead Box Protein M1 (analysis)</term>
<term>Forkhead Box Protein M1 (blood)</term>
<term>Glutaredoxins (analysis)</term>
<term>Glutaredoxins (blood)</term>
<term>Humans (MeSH)</term>
<term>Inflammation (complications)</term>
<term>Inflammation (diagnosis)</term>
<term>Inflammation (metabolism)</term>
<term>Intensive Care Units (organization & administration)</term>
<term>Male (MeSH)</term>
<term>Membrane Proteins (analysis)</term>
<term>Membrane Proteins (blood)</term>
<term>MicroRNAs (analysis)</term>
<term>MicroRNAs (blood)</term>
<term>MicroRNAs (metabolism)</term>
<term>Middle Aged (MeSH)</term>
<term>Oxidative Stress (MeSH)</term>
<term>Patient Outcome Assessment (MeSH)</term>
<term>Peroxidase (analysis)</term>
<term>Peroxidase (blood)</term>
<term>Peroxiredoxin III (analysis)</term>
<term>Peroxiredoxin III (blood)</term>
<term>Prospective Studies (MeSH)</term>
<term>RNA, Messenger (analysis)</term>
<term>RNA, Messenger (blood)</term>
<term>RNA, Messenger (metabolism)</term>
<term>Selenoproteins (analysis)</term>
<term>Selenoproteins (blood)</term>
<term>Shock, Septic (metabolism)</term>
<term>Shock, Septic (physiopathology)</term>
<term>Superoxide Dismutase (analysis)</term>
<term>Superoxide Dismutase (blood)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>ARN messager (analyse)</term>
<term>ARN messager (métabolisme)</term>
<term>ARN messager (sang)</term>
<term>Adulte (MeSH)</term>
<term>Adulte d'âge moyen (MeSH)</term>
<term>Brésil (MeSH)</term>
<term>Choc septique (métabolisme)</term>
<term>Choc septique (physiopathologie)</term>
<term>Exosomes (anatomopathologie)</term>
<term>Exosomes (composition chimique)</term>
<term>Exosomes (métabolisme)</term>
<term>Femelle (MeSH)</term>
<term>Glutarédoxines (analyse)</term>
<term>Glutarédoxines (sang)</term>
<term>Humains (MeSH)</term>
<term>Inflammation (complications)</term>
<term>Inflammation (diagnostic)</term>
<term>Inflammation (métabolisme)</term>
<term>Myeloperoxidase (analyse)</term>
<term>Myeloperoxidase (sang)</term>
<term>Mâle (MeSH)</term>
<term>Peroxiredoxin III (analyse)</term>
<term>Peroxiredoxin III (sang)</term>
<term>Protéine M1 à motif en tête de fourche (analyse)</term>
<term>Protéine M1 à motif en tête de fourche (sang)</term>
<term>Protéines membranaires (analyse)</term>
<term>Protéines membranaires (sang)</term>
<term>Stress oxydatif (MeSH)</term>
<term>Sujet âgé (MeSH)</term>
<term>Superoxide dismutase (analyse)</term>
<term>Superoxide dismutase (sang)</term>
<term>Sélénoprotéines (analyse)</term>
<term>Sélénoprotéines (sang)</term>
<term>Unités de soins intensifs (organisation et administration)</term>
<term>microARN (analyse)</term>
<term>microARN (métabolisme)</term>
<term>microARN (sang)</term>
<term>Études prospectives (MeSH)</term>
<term>Évaluation des résultats des patients (MeSH)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Forkhead Box Protein M1</term>
<term>Glutaredoxins</term>
<term>Membrane Proteins</term>
<term>MicroRNAs</term>
<term>Peroxidase</term>
<term>Peroxiredoxin III</term>
<term>RNA, Messenger</term>
<term>Selenoproteins</term>
<term>Superoxide Dismutase</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Forkhead Box Protein M1</term>
<term>Glutaredoxins</term>
<term>Membrane Proteins</term>
<term>MicroRNAs</term>
<term>Peroxidase</term>
<term>Peroxiredoxin III</term>
<term>RNA, Messenger</term>
<term>Selenoproteins</term>
<term>Superoxide Dismutase</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>MicroRNAs</term>
<term>RNA, Messenger</term>
</keywords>
<keywords scheme="MESH" type="geographic" xml:lang="en"><term>Brazil</term>
</keywords>
<keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>ARN messager</term>
<term>Glutarédoxines</term>
<term>Myeloperoxidase</term>
<term>Peroxiredoxin III</term>
<term>Protéine M1 à motif en tête de fourche</term>
<term>Protéines membranaires</term>
<term>Superoxide dismutase</term>
<term>Sélénoprotéines</term>
<term>microARN</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Exosomes</term>
</keywords>
<keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Exosomes</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Inflammation</term>
</keywords>
<keywords scheme="MESH" qualifier="composition chimique" xml:lang="fr"><term>Exosomes</term>
<term>Inflammation</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Inflammation</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Inflammation</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Exosomes</term>
<term>Inflammation</term>
<term>Shock, Septic</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>ARN messager</term>
<term>Choc septique</term>
<term>Exosomes</term>
<term>Inflammation</term>
<term>microARN</term>
</keywords>
<keywords scheme="MESH" qualifier="organisation et administration" xml:lang="fr"><term>Unités de soins intensifs</term>
</keywords>
<keywords scheme="MESH" qualifier="organization & administration" xml:lang="en"><term>Intensive Care Units</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Exosomes</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Choc septique</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Shock, Septic</term>
</keywords>
<keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>ARN messager</term>
<term>Glutarédoxines</term>
<term>Myeloperoxidase</term>
<term>Peroxiredoxin III</term>
<term>Protéine M1 à motif en tête de fourche</term>
<term>Protéines membranaires</term>
<term>Superoxide dismutase</term>
<term>Sélénoprotéines</term>
<term>microARN</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Oxidative Stress</term>
<term>Patient Outcome Assessment</term>
<term>Prospective Studies</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Brésil</term>
<term>Femelle</term>
<term>Humains</term>
<term>Mâle</term>
<term>Stress oxydatif</term>
<term>Sujet âgé</term>
<term>Études prospectives</term>
<term>Évaluation des résultats des patients</term>
</keywords>
<keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Brésil</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b>
</p>
<p>Exosomes isolated from plasma of patients with sepsis may induce vascular apoptosis and myocardial dysfunction by mechanisms related to inflammation and oxidative stress. Despite previous studies demonstrating that these vesicles contain genetic material related to cellular communication, their molecular cargo during sepsis is relatively unknown. In this study, we evaluated the presence of microRNAs (miRNAs) and messenger RNAs (mRNAs) related to inflammatory response and redox metabolism in exosomes of patients with septic shock.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>METHODS</b>
</p>
<p>Blood samples were collected from 24 patients with septic shock at ICU admission and after 7 days of treatment. Twelve healthy volunteers were used as control subjects. Exosomes were isolated by ultracentrifugation, and their miRNA and mRNA content was evaluated by qRT-PCR array.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>RESULTS</b>
</p>
<p>As compared with healthy volunteers, exosomes from patients with sepsis had significant changes in 65 exosomal miRNAs. Twenty-eight miRNAs were differentially expressed, both at enrollment and after 7 days, with similar kinetics (18 miRNAs upregulated and 10 downregulated). At enrollment, 35 differentially expressed miRNAs clustered patients with sepsis according to survival. The pathways enriched by the miRNAs of patients with sepsis compared with control subjects were related mostly to inflammatory response. The comparison of miRNAs from patients with sepsis according to hospital survival demonstrated pathways related mostly to cell cycle regulation. At enrollment, sepsis was associated with significant increases in the expression of mRNAs related to redox metabolism (myeloperoxidase, 64-fold; PRDX3, 2.6-fold; SOD2, 2.2-fold) and redox-responsive genes (FOXM1, 21-fold; SELS, 16-fold; GLRX2, 3.4-fold). The expression of myeloperoxidase mRNA remained elevated after 7 days (65-fold).</p>
</div>
<div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b>
</p>
<p>Exosomes from patients with septic shock convey miRNAs and mRNAs related to pathogenic pathways, including inflammatory response, oxidative stress, and cell cycle regulation. Exosomes may represent a novel mechanism for intercellular communication during sepsis.</p>
</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">29540208</PMID>
<DateCompleted><Year>2018</Year>
<Month>10</Month>
<Day>01</Day>
</DateCompleted>
<DateRevised><Year>2019</Year>
<Month>10</Month>
<Day>30</Day>
</DateRevised>
<Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1466-609X</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>22</Volume>
<Issue>1</Issue>
<PubDate><Year>2018</Year>
<Month>Mar</Month>
<Day>15</Day>
</PubDate>
</JournalIssue>
<Title>Critical care (London, England)</Title>
<ISOAbbreviation>Crit Care</ISOAbbreviation>
</Journal>
<ArticleTitle>Exosomes from patients with septic shock convey miRNAs related to inflammation and cell cycle regulation: new signaling pathways in sepsis?</ArticleTitle>
<Pagination><MedlinePgn>68</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1186/s13054-018-2003-3</ELocationID>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Exosomes isolated from plasma of patients with sepsis may induce vascular apoptosis and myocardial dysfunction by mechanisms related to inflammation and oxidative stress. Despite previous studies demonstrating that these vesicles contain genetic material related to cellular communication, their molecular cargo during sepsis is relatively unknown. In this study, we evaluated the presence of microRNAs (miRNAs) and messenger RNAs (mRNAs) related to inflammatory response and redox metabolism in exosomes of patients with septic shock.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">Blood samples were collected from 24 patients with septic shock at ICU admission and after 7 days of treatment. Twelve healthy volunteers were used as control subjects. Exosomes were isolated by ultracentrifugation, and their miRNA and mRNA content was evaluated by qRT-PCR array.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">As compared with healthy volunteers, exosomes from patients with sepsis had significant changes in 65 exosomal miRNAs. Twenty-eight miRNAs were differentially expressed, both at enrollment and after 7 days, with similar kinetics (18 miRNAs upregulated and 10 downregulated). At enrollment, 35 differentially expressed miRNAs clustered patients with sepsis according to survival. The pathways enriched by the miRNAs of patients with sepsis compared with control subjects were related mostly to inflammatory response. The comparison of miRNAs from patients with sepsis according to hospital survival demonstrated pathways related mostly to cell cycle regulation. At enrollment, sepsis was associated with significant increases in the expression of mRNAs related to redox metabolism (myeloperoxidase, 64-fold; PRDX3, 2.6-fold; SOD2, 2.2-fold) and redox-responsive genes (FOXM1, 21-fold; SELS, 16-fold; GLRX2, 3.4-fold). The expression of myeloperoxidase mRNA remained elevated after 7 days (65-fold).</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Exosomes from patients with septic shock convey miRNAs and mRNAs related to pathogenic pathways, including inflammatory response, oxidative stress, and cell cycle regulation. Exosomes may represent a novel mechanism for intercellular communication during sepsis.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Real</LastName>
<ForeName>Juliana Monte</ForeName>
<Initials>JM</Initials>
<AffiliationInfo><Affiliation>Research and Education Institute, Hospital Sirio-Libanes, Rua Professor Daher Cutait 69, São Paulo, SP, 01539-001, Brazil.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Sao Paulo State Cancer Institute, University of São Paulo, São Paulo, Brazil.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Hospital do Servidor Publico Estadual de São Paulo, São Paulo, Brazil.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ferreira</LastName>
<ForeName>Ludmila Rodrigues Pinto</ForeName>
<Initials>LRP</Initials>
<AffiliationInfo><Affiliation>Morphology Department, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Laboratory of Immunology, Heart Institute, University of São Paulo, School of Medicine, São Paulo, Brazil.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Esteves</LastName>
<ForeName>Gustavo Henrique</ForeName>
<Initials>GH</Initials>
<AffiliationInfo><Affiliation>Universidade Estadual da Paraíba, Centro de Ciências e Tecnologia, Campina Grande, Brazil.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Koyama</LastName>
<ForeName>Fernanda Christtanini</ForeName>
<Initials>FC</Initials>
<AffiliationInfo><Affiliation>Research and Education Institute, Hospital Sirio-Libanes, Rua Professor Daher Cutait 69, São Paulo, SP, 01539-001, Brazil.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Ludwig Institute for Cancer Research, São Paulo, Brazil.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Dias</LastName>
<ForeName>Marcos Vinícius Salles</ForeName>
<Initials>MVS</Initials>
<AffiliationInfo><Affiliation>International Research Center, A.C.Camargo Cancer Center, São Paulo, Brazil.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bezerra-Neto</LastName>
<ForeName>João Evangelista</ForeName>
<Initials>JE</Initials>
<AffiliationInfo><Affiliation>Sao Paulo State Cancer Institute, University of São Paulo, São Paulo, Brazil.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Cunha-Neto</LastName>
<ForeName>Edécio</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>Laboratory of Immunology, Heart Institute, University of São Paulo, School of Medicine, São Paulo, Brazil.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Division of Clinical Immunology and Allergy, School of Medicine, University of São Paulo, São Paulo, Brazil.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Machado</LastName>
<ForeName>Flavia Ribeiro</ForeName>
<Initials>FR</Initials>
<AffiliationInfo><Affiliation>Federal University of São Paulo, São Paulo, Brazil.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Salomão</LastName>
<ForeName>Reinaldo</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Federal University of São Paulo, São Paulo, Brazil.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Azevedo</LastName>
<ForeName>Luciano Cesar Pontes</ForeName>
<Initials>LCP</Initials>
<Identifier Source="ORCID">http://orcid.org/0000-0001-6759-3910</Identifier>
<AffiliationInfo><Affiliation>Research and Education Institute, Hospital Sirio-Libanes, Rua Professor Daher Cutait 69, São Paulo, SP, 01539-001, Brazil. lucianoazevedo@uol.com.br.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Emergency Medicine, University of São Paulo, São Paulo, Brazil. lucianoazevedo@uol.com.br.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>10/52554-1</GrantID>
<Agency>Fundação de Amparo à Pesquisa do Estado de São Paulo</Agency>
<Country></Country>
</Grant>
</GrantList>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D064888">Observational Study</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2018</Year>
<Month>03</Month>
<Day>15</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>Crit Care</MedlineTA>
<NlmUniqueID>9801902</NlmUniqueID>
<ISSNLinking>1364-8535</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000072278">Forkhead Box Protein M1</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C516008">GLRX2 protein, human</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D054477">Glutaredoxins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D008565">Membrane Proteins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D035683">MicroRNAs</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D012333">RNA, Messenger</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C487710">SELENOS protein, human</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D051140">Selenoproteins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 1.11.1.15</RegistryNumber>
<NameOfSubstance UI="C516115">PRDX3 protein, human</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 1.11.1.15</RegistryNumber>
<NameOfSubstance UI="D061105">Peroxiredoxin III</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 1.11.1.7</RegistryNumber>
<NameOfSubstance UI="D009195">Peroxidase</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 1.15.1.1</RegistryNumber>
<NameOfSubstance UI="D013482">Superoxide Dismutase</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 1.15.1.1</RegistryNumber>
<NameOfSubstance UI="C431683">superoxide dismutase 2</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D001938" MajorTopicYN="N" Type="Geographic">Brazil</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D055354" MajorTopicYN="N">Exosomes</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000072278" MajorTopicYN="N">Forkhead Box Protein M1</DescriptorName>
<QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName>
<QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D054477" MajorTopicYN="N">Glutaredoxins</DescriptorName>
<QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName>
<QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007249" MajorTopicYN="N">Inflammation</DescriptorName>
<QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName>
<QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007362" MajorTopicYN="N">Intensive Care Units</DescriptorName>
<QualifierName UI="Q000458" MajorTopicYN="N">organization & administration</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008565" MajorTopicYN="N">Membrane Proteins</DescriptorName>
<QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName>
<QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D035683" MajorTopicYN="N">MicroRNAs</DescriptorName>
<QualifierName UI="Q000032" MajorTopicYN="Y">analysis</QualifierName>
<QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018384" MajorTopicYN="N">Oxidative Stress</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D063868" MajorTopicYN="N">Patient Outcome Assessment</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009195" MajorTopicYN="N">Peroxidase</DescriptorName>
<QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName>
<QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D061105" MajorTopicYN="N">Peroxiredoxin III</DescriptorName>
<QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName>
<QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011446" MajorTopicYN="N">Prospective Studies</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012333" MajorTopicYN="N">RNA, Messenger</DescriptorName>
<QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName>
<QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D051140" MajorTopicYN="N">Selenoproteins</DescriptorName>
<QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName>
<QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012772" MajorTopicYN="N">Shock, Septic</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
<QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName>
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Exosomes from patients with septic shock convey miRNAs related to inflammation and cell cycle regulation: new signaling pathways in sepsis?

Exosomes from patients with septic shock convey miRNAs related to inflammation and cell cycle regulation: new signaling pathways in sepsis?

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